New 2022 ESC/ERS definition of pulmonary hypertension: can we rely on the same non-invasive echocardiographic parameters?

Abstract Funding Acknowledgements Type of funding sources: None. Introduction The hemodynamic definition pulmonary hypertension (PH) has been updated, with lowering the mean arterial pressure (mPAP) threshold from 25 to 20 mmHg according new 2022 ESC/ERS Guidelines. Although there is no single echocardiographic parameter that reliably informs about PH status, some parameters cut-offs remained same, including a peak tricuspid regurgitation velocity (PTRV) >2.8m/s. potential underdiagnosis not evaluated. Objectives To evaluate screening power standard detect guidelines and establish predictors. Methods A prospective registry consecutive intermediate-high- high-risk PE pts submitted CDT in tertiary center was used. 3 months after procedure, patients were right heart catheterization echocardiogram screen chronic thromboembolic (CTEPH). According criteria, divided two groups, analyzed regarding their predictive power. ROC curve analysis performed optimal predicting guidelines. Results 17 (60% women, age 59 ± 16 years) included. Among these, 7 (41,2%) diagnosed pre-capillary by RHC at follow-up. parameters, PTRV (p 0.015), presence (0.034) ventricle-pulmonary artery (RV-PA) coupling 0.041) significantly different between groups (Fig 1 A). Other such as ventricle dilation 0.849), TAPSE 0.100), annular s’ 0.646), outflow tract acceleration time 0.229) pericardial effusion 0.849) did show significant differences. Regarding PTRV, revealed an cut-off 2.6 m/s (pressure gradient 27mmHg) our population (AUC 0.911, p 0.030, Sn 71.4%, Sp 100%), compared conventional 2.8 31 mmHg) 0.470, 28.6%, 100%). use > allows reduce false negatives without losing specificity B, C D). Conclusion With recent update leads population. Lowering seems increase sensitivity, specificity. seem predict accurately PH.